Product Description

What is Palmitoylethanolamide powder?

Palmitoylethanolamide powder, produced in the body, is a natural painkiller ingredient in the endogenous fatty acid amide category and synthesized within your own body. We call it endogenous. Palmitoylethanolamide pea powder is widely applied in sports nutrition supplements and joint health formulas worldwide, especially in the United States, Australia, UK, Canada, and EU countries like the Netherlands, Belgium, and Italy.

Palmitoylethanolamide pea powder is a pretty long word. If it is your first time come across it, you may wonder how to memorize or pronounce it. Well, palmitoylethanolamide is a word that consists of three words:

Palmitoyl / pɑːmɪ’tɔɪl/ +Ethanol / ‘eθənɔːl/ +Amide / ‘æmɪd/

In our daily life, PEA (the first letter of each of the three words) refers to palmitoylethanolamide for short. However, PEA itself is a plant, and PEA protein is also applied in bodybuilding supplements as a vegetarian source of protein content. Don’t get them wrong.

PEA has been demonstrated to bind to a receptor in the cell nucleus (a nuclear receptor) and exerts a great variety of biological functions related to chronic pain and inflammation.

Palmitoylethanolamide chemical properties

The IUPAC name of PEA is N-(2-Hydroxyethyl) hexadecanamide. Raw Palmitoylethanolamide is usually in powder form, with molecule formula and weight as C18H37NO2 and 299.49 respectively. 544-31-0 is Palmitoylethanolamide’s CAS Registry Number and unique chemical identity.

Palmitoylethanolamide is practically insoluble in water and poorly soluble in most other aqueous solvents. Therefore, you may find that almost 99% of finished dosage formulations of palmitoylethanolamide are in capsules or soft gels.

Palmitoylethanolamide VS Phenylethylamine

In fact, they are two completely different ingredients. No relationship is between them. Phenylethylamine or Phenylethylamine HCl is most known as a mood and weight loss ingredient in many sports nutrition. While Palmitoylethanolamide powder is popularly known as a painkiller. The connection is that both compounds are abbreviated as PEA, and called PEA powder. So don’t get them wrong.

Palmitoylethanolamide vs anandamide

Many of our clients who buy bulk palmitoylethanolamide powder are also interested in Bulk anandamide powder and anandamide oil from us. Therefore, what’s the relation between them?

Both Palmitoylethanolamide pea powder and anandamide are endogenous fatty acid amides in our human bodies.

According to Wikipedia, Palmitoylethanolamide PEA and related compounds such as anandamide seem to have synergistic effects in models of pain and analgesia.

Gas-chromatography/mass-spectrometry measurements show that the levels of anandamide and PEA in the skin are enough to cause a tonic activation of local cannabinoid receptors.

In one study, the data shows that anandamide and PEA activate pharmacologically distinct receptors and that these two substances can be produced simultaneously in tissues. When injected together in equal amounts, anandamide and PEA inhibited the early phase of formalin-evoked pain behavior with a potency that was approximately 100 fold greater than each of the compounds separately (Fig. 3a). A similar synergistic potentiation occurred in the late phase, on which anandamide had no effect when given alone (Figs 1a and 3b). Earlier administration of either CB1 or CB2 antagonists entirely blocked the response.

Anandamide and PEA synergistically inhibit formalin-evoked nociception.

a, Early phase.

b, Late phase (open squares, anandamide; filled diamonds, PEA; filled circles, anandamide plus PEA). Equal amounts of anandamide and PEA were administered by i.pl. Injection at the doses indicated on the abscissa.

In addition, the FAAH enzyme is able to break down both anandamide and palmitoylethanolamide in the body. If more PEA and AEA powder are added, it will take more time for FAAH to work and thus lasts longer positive effects.