According to the drug classification standard of FDA, azelaic acid belongs to class B drug, which can be safely used during pregnancy and lactation.It can inhibit the production and action of reactive oxygen species, which is beneficial to the anti-inflammatory and various therapeutic effects of drugs. By reducing the synthesis of filamentous keratin, it can reduce excessive keratinization of hair follicles and has good permeability to the skin.
It can promote the absorption of the product to the skin by adding azelaic acid to cream cosmetics. In addition, azelaic acid can inhibit bacteria and regulate normal sebum secretion, but its compatibility is greatly limited due to its two natural defects of poor water solubility and high melting point.The level of androgen testosterone in the body is too high, and it passes 5 years in the sebaceous gland- α The function of reductase is transformed into dihydrotestosterone, which leads to the hyperfunction of sebaceous gland, resulting in excessive oil secretion. Azelaic acid can competitively inhibit 5- α The function of reductase inhibits the conversion of excessive androgen into dihydrotestosterone, and finally inhibits the excessive secretion of free fatty acids in sebaceous glands.
It can inhibit the production of reactive oxygen free radicals and play an anti-inflammatory role. The hydroxylation of aromatic compounds induced by reactive oxygen groups and the peroxidation of arachidonic acid were inhibited in vitro.
The 40% water soluble azelaic acid produced by Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has a high content and is added less in skin care products. At room temperature, it is put into water to stir and dissolve, and the aqueous solution is clear and transparent.
Excessive keratosis of sebaceous ducts in hair follicles will block hair follicles, while azelaic acid has an anti keratotic effect on normal skin and acne infected skin, which can reduce the synthesis of filamentous keratin and prevent excessive keratosis of hair follicles.